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CYP
    发布时间: 2019-01-16 09:56    

重组酶是利用分子生物学方法，经过基因克隆表达纯化得到的单一类型的酶，在代谢表型的研究中便于验证药物的代谢通路，计算参与药物代谢的亚酶的贡献度。相对于微粒体中以天然比例的各种代谢亚酶的混合，是一种过表达的单一的亚型，较易放大该亚酶参与代谢的贡献度。

CYP
A.  Human Reductase   Bactosomes
CYP001CYP1A2 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP002CYP3A4 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP005CYP3A4 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP006CYP2C9 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP007CYP2D6 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP008CYP2C19 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP009CYP2E1 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP010CYP3A4 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP011CYP2A6 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP012CYP1A2 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP013CYP2D6 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP014CYP1A1 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP015CYP3A5 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP016CYP2B6 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP017CYP2C8 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP018CYP1A1 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP019CYP2C9 High Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP020CYP2B6 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP021CYP1B1*3 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP022CYP2C18 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP023CYP1B1 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP024CYP1B1*4 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP025CYP4A11 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP026CYP4A11 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP027CYP2D6*2 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP028CYP2C19 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP029CYP2D6*10  Reductase Bactosomes,   Human rCYP Enzyme, 1 nmol/vial.
CYP030CYP2D6*39 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.


CYP031CYP2C9*2  Reductase Bactosomes,   Human rCYP Enzyme, 1 nmol/vial.
CYP032CYP2A13 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP033CYP2A13 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP034CYP2J2 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP035CYP3A4 Low Reductase Bactosomes, plus b5,    Human rCYP Enzyme, 1 nmol/vial.
CYP036CYP2E1 Reductase Bactosomes, plus b5 Human rCYP Enzyme, 1 nmol/vial.
CYP037CYP2C9 High Reductase Bactosomes, plus b5,  Human rCYP Enzyme, 1 nmol/vial.
CYP038CYP2C9 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP039CYP2C9*3  Reductase Bactosomes,   Human rCYP Enzyme, 1 nmol/vial.
CYP040CYP4F2B Low Reductase Bactosomes, Human rCYP Enzyme, 1nmol/vial 
CYP041CYP2B6 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP042CYP2C9*2  Reductase Bactosomes,   plus b5,  Human rCYP Enzyme, 1   nmol/vial.
CYP043CYP4A11 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial
CYP044CYP2C9*3  Reductase Bactosomes,   plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP045CYP3A5 Low Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP046CYP3A5 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP047CYP2C8 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial.
CYP048CYP3A5 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial
CYP049CYP2C8 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP052CYP2C8 Low Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial.
CYP053CYP3A7 Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP054CYP3A7 Low Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial
CYP055CYP4F3B Low Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP056CYP4F3B High Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP057CYP4F3B Low Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial
CYP058CYP4F3B High Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1   nmol/vial
CYP059CYP3A7 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP060CYP3A7 Reductase Bactosomes, plus b5, Human rCYP Enzyme, 1 nmol/vial
CYP061CYP2B6 Low Reductase Bactosomes, plus b5, Human rCYP Eznyme 1 nmol/vial
CYP062CYP2C19 Low Reductase Bactosomes, plus b5, Human rCYP Enzyme 1 nmol/vial
CYP063CYP2C19 High Reductase Bactosomes, plus b5, Human rCYP Enzyme 1 nmol/vial
CYP064CYP2A6 High Reductase Bactosome, plus b5, Human rCYP Enzyme 1 nmol/vial
CYP065CYP17A1 Low Reductase Bactosome, Human rCYP Enzyme 1 nmol/vial
CYP066CYP17A1 High Reductase Bactosome, Human rCYP Enzyme 1 nmol/vial


B. Dog Enzymes
CYP300Dog CYP1A1 Low Reductase Bactosomes, 1 nmol/vial
CYP301Dog CYP2B11 Low Reductase    Bactosomes, 1 nmo/vial
CYP302Dog CYP2C21 Low Reductase    Bactosomes, 1 nmol/vial
CYP303Dog CYP2C41 Low Reductase Bactosomes, 1 nmol/vial
CYP304Dog CYP2D15 Low Reductase    Bactosomes, 1 nmol/vial
CYP305Dog CYP3A12 Low Reductase Bactosomes,    1 nmol/vial
CYP306Dog CYP3A26 Low Reductase    Bactosomes, 1 nmol/vial
CYP307Dog CYP1A2 Low Reductase    Bactosomes, 1 nmol/vial


C Rat Enzymes
CYP360Rat CYP3A9 Low Reductase Bactosomes, 1 nmol/vial
CYP361Rat CYP2D4 Low Reductase Bactosomes, 1 nmol/vial
CYP362Rat CYP2D18 Low Reductase Bactosomes, 1 nmol/vial
CYP363Rat CYP1B1 and rat CYP-reductase coexpressed in Escherichia coli 1 nmol   cytochrome P450
CYP364Rat CYP1A2 and rat CYP-reductase coexpressed in Escherichia coli 1 nmol   cytochrome P450
CYP365Rat CYP2C11 and rat CYP-reductase coexpressed in Escherichia coli 1 nmol   cytochrome P450
CYP366Rat CYP3A2 and rat CYP-reductase coexpressed in Escherichia coli  1 nmol cytochrome P450


D. Mouse Enzymes
CYP400Mouse CYP2B10 Low Reductase Bactosomes, 1nmol/vial
CYP401Mouse CYP3A11 Low Reductase Bactosomes, 1nmol/vial
CYP402Mouse CYP1B1 Low Reductase Bactosomes, 1nmol/vial


E. Monkey Enzymes
CYP330Monkey CYP2C8 Low Reductase Bactosomes, 1 nmol/vial
CYP331Monkey CYP2C9 Low Reductase    Bactosomes, 1 nmo/vial
CYP332Monkey CYP2C19 Low Reductase    Bactosomes, 1 nmol/vial
CYP333Monkey CYP2C76 Low Reductase Bactosomes, 1 nmol/vial
CYP334Monkey CYP3A4 Low Reductase    Bactosomes, 1 nmol/vial
CYP335Monkey CYP3A5 Low Reductase Bactosomes,    1 nmol/vial


F.    Reductase
CYP004Human Reductase Bactosomes, 4 nmol/vial.


G.    Control
CYP003Control Bactosomes, 10 mg/vial.


H.    Screening Kits
CYP450.HHigh Reductase Screening Kit, includes 1 vial each:  

CYP001:  CYP1A2 Reductase   Bactosomes, 1 nmol.

CYP019:  CYP2C9 High Reductase   Bactosomes, 1 nmol.

CYP008:  CYP2C19  Reductase Bactosomes, 1 nmol.

CYP007:  CYP2D6 Reductase   Bactosomes, 1 nmol.

CYP002:  CYP3A4 Reductase   Bactosomes, 1 nmol.

CYP003:  Control Bactosomes, 10 mg.


CYP450.LLow Reductase Screening Kit, includes 1 vial each:  

CYP012:  CYP1A2 Low Reductase   Bactosomes, 1 nmol.

CYP006:  CYP2C9 Reductase   Bactosomes, 1 nmol.

CYP028:  CYP2C19  Reductase Bactosomes, 1 nmol.

CYP013:  CYP2D6 Low Reductase   Bactosomes, 1 nmol.

CYP010:  CYP3A4 Low Reductase   Bactosomes, 1 nmol.

CYP003:  Control Bactosomes, 10 mg.


I. Other Enzymes
CYP099Control E. coli Cytosol (1 mg cytosolic protein)
CYP100Human SULT1A1*1 (1mg cytosolic protein)
CYP101Human SULT1A3 (1 mg cytosolic protein)
CYP102Human SULT1B1 (1 mg cytosolic protein)
CYP103Human SULT1E1 (1 mg cytosolic protein)
CYP104Human SULT2A1 (1 mg cytosolic protein)
CYP105Human SULT1A1*2 (1 mg cytosolic protein)
CYP106Human SULT1A2 (1 mg cytosolic protein)
CYP107Human SULT1C2 (1 mg cytosolic protein)
CYP108Human SULT1C4 (1 mg cytosolic protein)
CYP120Human GSTA1 (1 mg cytosolic protein)
CYP121Human GSTM1 (1 mg cytosolic protein)
CYP150Human Aldehyde Oxidase; cytosolic extract of the full-length recombinant   protein expressed in E. coli, 250uL
CYP151Human Aldehyde Dehydrogenase 1A1 (1 mg cytosolic protein)
CYP152Human Carboxylesterase 1 Bactosomes, 1 mg
CYP153Human Carboxylesterase 2 Bactosomes, 1 mg
CYP200UGT1A6 Bactosomes, Human UDP-glucuronosyltransferase 1nmol/vial


J. Easy CYPS
CYP/EZ001EasyCyp CYP1A2 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ002EasyCyp CYP3A4 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ003EasyCyp Control 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ005EasyCyp CYP3A4 Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ006EasyCyp CYP2C9 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ007EasyCyp CYP2D6 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ008EasyCyp CYP2C19 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ009EasyCyp CYP2E1 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ010EasyCyp CYP3A4 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ011EasyCyp CYP2A6 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ012EasyCyp CYP1A2 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ013EasyCyp CYP2D6 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ014EasyCyp CYP1A1 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ015EasyCyp CYP3A5 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ016EasyCyp CYP2B6 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ017EasyCyp CYP2C8 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ018EasyCyp CYP1A1 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ019EasyCyp CYP2C9 High Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ020EasyCyp CYP2B6 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ021EasyCyp CYP1B1*3 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ022EasyCyp CYP2C18 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ023EasyCyp CYP1B1 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ024EasyCyp CYP1B1*4 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ025EasyCYP CYP4A11 Low Reductase 0.5 nmol P450 at 1 nmol/mL, 10 mg/ml   protein
CYP/EZ026EasyCyp CYP4A11 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ027EasyCyp CYP2D6*2 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ028EasyCyp CYP2C19 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ029EasyCyp CYP2D6*10 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ030EasyCyp CYP2D6*39 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein


CYP/EZ031EasyCyp CYP2C9*2 Reductase 0.5 nmol P450 at 1 nmol/ml. 10 mg/ml protein
CYP/EZ032EasyCyp CYP2A13 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ033EasyCyp CYP2A13 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ034EasyCyp CYP2J2 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ035EasyCyp CYP3A4 Low Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ036EasyCyp CYP2E1 Reductase plus b5    0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ037EasyCyp CYP2C9 High Reductase plus b5    0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ038EasyCyp CYP2C9 Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ040EasyCyp CYP4F2 Low Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ041EasyCyp CYP2B6 Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ042EasyCyp CYP2C9*2 Reductase plus b5 0.5nmol P450 at 1 nmol/ml. 10 mg/ml   protein
CYP/EZ043EasyCyp CYP4A11 Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ044EasyCyp CYP2C9*3  Reductase plus b5   0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ045EasyCYP CYP3A5 Low Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ046EasyCYP CYP3A5 Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ047EasyCYP CYP2C8 Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml protein
CYP/EZ048EasyCYP CYP3A5 Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ049EasyCyp CYP2C8 Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ052EasyCYP CYP2C8 Low Reductase plus b5 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ055EasyCYP CYP4F3B Low Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ056EasyCYP CYP4F3B High Reductase 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ057EasyCYP CYP4F3B Low Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ058EasyCYP CYP4F3B High Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ059EasyCYP CYP3A7 High Reductase, 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ060EasyCYP CYP3A7 Low Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ061EasyCYP CYP2B6 Low Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ062EasyCyp CYP2C19 Low Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ063EasyCYP CYP2C18 High Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ064EasyCYP CYP2A6 High Reductase, plus b5, 0.5 nmol P450 at 1 nmol/ml, 10   mg/ml protein
CYP/EZ065EasyCYP CYP17A1 Low Reducatse, 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein
CYP/EZ066EasyCYP CYP17A1 High Reductase, 0.5 nmol P450 at 1 nmol/ml, 10 mg/ml   protein


K.   Metabolites & Substrates
CYP5004-hydroxydiclofenac, 0.1mg
CYP500-54-hydroxydiclofenac, 5 mg
CYP5016alpha-hydroxypaclitaxel, 0.1mg
CYP501-56alpha-hydroxypaclitaxel, 5.0mg
CYP502[1-14C] Lauric Acid, 50 uCi
CYP503[1-14C] 11-hydroxylauric acid, 50 uCi
CYP504[1-14C] 12-hydroxylauric acid, 50 uCi
CYP505Tolbutamide, 100 mg
CYP506Hydroxytolbutamide, 10 mg
CYP507Carboxytolbutamide, 10 mg
CYP508Carboxytolbutamide methyl ester, 10 mg
CYP509Tolbutamide Kit (CYP505-CYP508)
CYP5107-ethoxyresorufin, 10 mg
CYP511Resorufin, 100 mg
CYP5127-benzyloxyquinoline, 10 mg
CYP5137-hydroxyquinoline, 10 mg
CYP514[14C] 7-ethoxycoumarin, 50 uCi
CYP515-10MAMC, 10 mg
CYP515-25MAMC, 25 mg
CYP516HAMC, 10 mg
CYP517-107-methoxy-4-trifluoromethylcoumarin, 10mg
CYP517-257-methoxy-4-trifluoromethylcoumarin, 25 mg
CYP5197-hydroxy-4-trifluoromethylcoumarin, 10 mg
CYP520Omeprazole. 1G
CYP521-103-O-methyfluorescein, 10 mg
CYP521-253-O-methyfluorescein, 25 mg
CYP522-10Tienilic Acid, 10 mg
CYP522-25Tienilic Acid, 25 mg
CYP523-25Paclitaxel, 25 mg
CYP523-100Paclitaxel, 100 mg
CYP524-100Ketoconazole, 100 mg
CYP524-1000Ketoconazole, 1g
CYP525Diclofenac, 10g
CYP526Amodiaquine dihydrochloride dihydrate, 5g
CYP527-10Desethylamodiaquine, 10mg
CYP527-25Desethylamodiaquine, 25mg
CYP528Terfenadine, 5g
CYP529-10R-(-)-N-benzylphenobarbital, 10 mg
CYP529-25R-(-)-N-benzylphenobarbital, 25 mg
CYP530-10Montelukast sodium, 10 mg
CYP530-25Montelukast sodium, 25 mg
CYP531-10Diethoxyfluorescein (DEF), 10 mg
CYP531-25Diethoxyfluorescein (DEF), 25 mg
CYP532S-mephenytoin, 5.0 mg
CYP533(±)-4’-hydroxymephenytoin, 5.0 mg